I don't believe that runs that happen when a team is down by 25 or 30 are statistically meaningful, even if they lead to a timeout. A run that forces a lead change or a change in momentum of the game is a different story.
It's quite common when watching the UConn women that they go up by 40-50 points, put in the weaker bench players and then the opposing team makes a run that leads Geno to call a timeout. It's not because the game is losable, it's because it's a teaching moment as the team is not playing at the level he expects. Similarly I think Jay Wright saw his team taking the foot off the gas pedal and did not like it. His Villanova team has been blowing out a lot of people lately, Georgetown by 33 and most recently they beat Providence by 20. So he wants to guard against them getting too relaxed.
I can think of two significant runs by UConn men, in past years, to win huge games. There was an 11-0 run to end the Big East championship game in 1996, punctuated by Ray Allen's off balance jumper at the buzzer to win it, and the 12-0 run at the end of the game to beat Duke in the 2004 Final 4, only interrupted by a meaningless desperation 3 at the buzzer. Before that Duke did not get a clean look at a shot in the last 4 minutes of that game. They got bottled up, big time.
I also recall the monumental run that turned a 25 point second half deficit against UMass into an 11 point win when Jim Calhoun inserted Rashad Anderson, then a freshman who up until that game had barely played, and the kid started raining 3s into the basket, which inspired the whole team. That was probably the most incredible run I can ever remember UConn going on. I thought that game was lost. UMass had a good team that year, very solid big men as I recall. Calhoun was not getting what he wanted from the team on offense and Anderson proved to be the spark that night. And it would signal the big things that were to come from him down the road as one of the more amazing 3 point shooters in UConn history.
Now those are real runs. The run UConn had against Villanova was a "gimme run" and I don't even consider those to be real basketball runs. Not when a team is down by more than 15 and the lead does not change. Those are gimme runs.