This preview from the Courant suggests that the 4 guard offense UConn deployed against Tulsa will not work against SMU, but I would prefer to start out with it and see what happens. SMU is a very good team, and UConn will need to play very well to beat them.
http://www.courant.com/sports/uconn-mens-basketball/hc-uconn-men-smu-advance-0214-20150213-story.html
http://www.courant.com/sports/uconn-mens-basketball/hc-uconn-men-smu-advance-0214-20150213-story.html