It's interesting that this would be the one game picked for Michigan--Michigan does have some classic trap games in its Big Ten schedule, including Northwestern, who is rated in the Top 25. But maybe the point is to pick a game nobody thinks Michigan will lose.
I think the Huskies have some upset potential, but it's not a great matchup for them--Michigan is generally very content to grind out a game. It's the Big Ten style. I think UConn can pull an upset if they can somehow, some way jump out to an early lead. Michigan has a young team and this will be there first road game, so we don't know how they'll respond to serious adversity. Scoring on Michigan's defense will not be easy, though, unless Whitmer has improved a lot form last year. Maybe a special teams break or two, a defensive touchdown...UConn needs to make something happen early.
The Huskies also must stuff the run. Michigan wants to be a running team, but they are not great at it, especially without Denard Robinson this year. UConn should be relatively well equipped to do this--at least it plays more to their strength than defending the pass. Gardner is going to suprise people with his passing this year, but still, Michigan is not loaded with receiving weapons, and just lost its #2 WR for the season. Beware Jeremy Gallon though. Little guy, plays big.
We'll also see how UConn reacts to having a lot of Michigan fans in the house. The home field advantage may be somewhat diminished. I expect a Michian win but if some things break right for UConn, an upset is plausible. As a Michigan fan, I'm a bit worried about this one.